RK-24466 (KIN 001-51)

中文名	RK-24466 (KIN 001-51)
英文名	7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
别名	化合物RK-24466 7-环戊基-5-(4-苯氧基苯基)-7H-吡咯并[2,3-D]嘧啶-4-胺
英文别名	RK24466 RK-24466 RK 24466 RK-24466 KIN 001-51 d]pyrimidin-4-ylamine RK-24466 (KIN 001-51) 7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-cyclopentyl-5-(4-phenoxyphenyl)-
CAS	213743-31-8
化学式	C23H22N4O
分子量	370.45
密度	1.30±0.1 g/cm3(Predicted)
沸点	605.1±55.0 °C(Predicted)
溶解度	DMSO: 17mg/ml在 ≤ 60 °C，可溶
酸度系数	5.75±0.30(Predicted)
存储条件	2-8°C
外观	白色固体
颜色	white
体外研究	RK-24466 is selective for Lck over a range of receptor, non-receptor tyrosine kinases and seronine/threonine kinases. RK-24466 are potent inhibitors of IL2 production in Jurkat cells stimulated with anti-CD3 antibody, being at least 100-fold more potent than PP1. RK-24466 displays remarkable cellular selectivity. RK-24466 significantly inhibits both VSMC proliferation and migration. RK-24466 suppresses VSMC proliferation and migration via down-regulating the protein kinase B (Akt) and extracellular signal regulated kinase (ERK) pathways, and it significantly decreases the expression of proliferating cell nuclear antigen (PCNA) and cyclin D1 and, the phosphorylation of retinoblastoma protein (pRb).
体内研究	RK-24466 inhibits T-cell receptor stimulated (a-CD3 mAb) IL-2 production in mice at low doses (ED 50 =4 mg/kg) after ip administration. However, efficacy is greatly reduced after oral administration (ED 50 =25 mg/kg) which is presumed to reflect poor intestinal absorption in the latter regimen. Inhibition of antigen specific T-cell immune responses is also seen for RK-24466. After administration of RK-24466 twice daily (100 mg/kg po) for 3 days during the in vivo priming phase, a 70% inhibition of IFNγ production is seen upon subsequent antigen-specific (KLH) challenge of lymphocytes from the draining lymph nodes in vitro . RK-24466 suppresses the migration of VSMCs from endothelium-removed aortic rings, as well as neointima formation following rat carotid balloon injury.
WGK Germany	3

RK-24466 (KIN 001-51) - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.699 ml	13.497 ml	26.994 ml
5 mM	0.54 ml	2.699 ml	5.399 ml
10 mM	0.27 ml	1.35 ml	2.699 ml
5 mM	0.054 ml	0.27 ml	0.54 ml

最后更新：2024-01-02 23:10:35

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产品名: 7-环戊基-5-(4-苯氧基苯基)-7H-吡咯并[2,3-d]嘧啶-4-胺去供应商网站查看询盘
CAS: 213743-31-8
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规格: YS141355-5mg
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CAS: 213743-31-8
产地: 中国上海
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产品描述: 中文名：7-环戊基-5-(4-苯氧基苯基)-7H-吡咯并[2,3-d]嘧啶-4-胺英文名:7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL- 更多

上海麦克林生化科技股份有限公司

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产品名: RK-24466 去供应商网站查看询盘
CAS: 213743-31-8
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规格: R880462
价格: 5mg-1474,1mg-398,1ml-720
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上海源叶生物科技有限公司

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产品名: RK-24466 (KIN 001-51) 去供应商网站查看询盘
CAS: 213743-31-8
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